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Amino Acids Quantitative by LC-MS/MS, CSF
Ordering Recommendation
Aid in the diagnosis of selected neurotransmitter disorders (eg, glycine encephalopathy, brain serine deficiency).
New York DOH Approval Status
Specimen Required
CSF.
Centrifuge CSF to separate and remove cellular material. Freeze supernatant. Transport 0.5 mL CSF. (Min: 0.3 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Clinical information is needed for appropriate interpretation. Additional required information includes age, gender, diet (e.g., TPN therapy), drug therapy, and family history. Biochemical Genetics Patient History Form is available on the ARUP Web site at https://www.aruplab.com/patienthistory or by contacting ARUP Client Services.
Ambient: Unacceptable; Refrigerated: 24 hours; Frozen: 1 month
Methodology
Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
2-5 days
Reference Interval
Effective November 18, 2019
| Components | Reference Interval | Components | Reference Interval |
| Alpha-Aminoadipic acid | Less than or equal to 2.0 µmol/L | Histidine | 7.0 - 24.0 µmol/L |
| Alpha-Amino-n-butyric acid | Less than or equal to 8.0 µmol/L | Homocitrulline | Less than or equal to 5.0 µmol/L |
| Alanine | 16.0 - 46.0 µmol/L | Homocystine | Less than or equal to 2.0 µmol/L |
| Alloisoleucine | Less than or equal to 2.0 µmol/L | Hydroxylysine | Less than or equal to 5.0 µmol/L |
| Anserine | Less than or equal to 7.0 µmol/L | Hydroxyproline | Less than or equal to 4.0 µmol/L |
| Arginine | 8.0 - 31.0 µmol/L | Isoleucine | Less than or equal to 12.0 µmol/L |
| Argininosuccinic acid | Less than or equal to 2.0 µmol/L | Leucine | 5.0 - 22.0 µmol/L |
| Asparagine | 4.0 - 13.0 µmol/L | Lysine | 10.0 - 36.0 µmol/L |
| Aspartic acid | Less than or equal to 5.0 µmol/L | Methionine | 2.0 - 7.0 µmol/L |
| Beta-Alanine | Less than or equal to 25.0 µmol/L | Ornithine | Less than or equal to 10.0 µmol/L |
| Beta-Aminoisobutyric acid | Less than or equal to 5.0 µmol/L | Phenylalanine | 6.0 - 20.0 µmol/L |
| Citrulline | Less than or equal to 5.0 µmol/L | Proline | Less than or equal to 5.0 µmol/L |
| Cystathionine | Less than or equal to 5.0 µmol/L | Sarcosine | Less than or equal to 5.0 µmol/L |
| Cystine | Less than or equal to 5.0 µmol/L | Serine | 18.0 - 66.0 µmol/L |
| Ethanolamine | Less than or equal to 40.0 µmol/L | Taurine | Less than or equal to 13.0 µmol/L |
| Gamma-Amino-n-butyric acid | Less than or equal to 5.0 µmol/L | Threonine | 14.0 - 59.0 µmol/L |
| Glutamic acid | Less than or equal to 5.0 µmol/L | Tryptophan | Less than or equal to 5.0 µmol/L |
| Glutamine | 330.0 - 630.0 µmol/L | Tyrosine | 5.0 - 23.0 µmol/L |
| Glycine | 5.0 - 20.0 µmol/L | Valine | 8.0 - 30.0 µmol/L |
Interpretive Data
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
82139
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0080138 | Alanine, CSF | 22657-1 |
| 0080139 | Arginine, CSF | 22656-3 |
| 0080141 | Asparagine, CSF | 26603-1 |
| 0080142 | Aspartic Acid, CSF | 22655-5 |
| 0080143 | Citrulline, CSF | 22654-8 |
| 0080144 | Cystine, CSF | 22653-0 |
| 0080148 | Glutamine, CSF | 22641-5 |
| 0080149 | Glutamic Acid, CSF | 22652-2 |
| 0080151 | Glycine, CSF | 22650-6 |
| 0080152 | Histidine, CSF | 9453-2 |
| 0080153 | Homocystine, CSF | 22660-5 |
| 0080154 | Hydroxyproline, CSF | 26596-7 |
| 0080156 | Isoleucine, CSF | 22659-7 |
| 0080157 | Leucine, CSF | 9412-8 |
| 0080158 | Lysine, CSF | 22651-4 |
| 0080159 | Methionine, CSF | 22648-0 |
| 0080161 | Ornithine, CSF | 22647-2 |
| 0080162 | Phenylalanine, CSF | 22646-4 |
| 0080163 | Proline, CSF | 22645-6 |
| 0080167 | Serine, CSF | 22644-9 |
| 0080168 | Taurine, CSF | 26614-8 |
| 0080169 | Threonine, CSF | 22643-1 |
| 0080171 | Tyrosine, CSF | 22642-3 |
| 0080172 | Valine, CSF | 22649-8 |
| 0080173 | Amino Acids, CSF Interpretation | 48767-8 |
| 2011976 | Homocitrulline, CSF | 55875-9 |
| 2011977 | Hydroxylysine, CSF | 26595-9 |
| 2011983 | Sarcosine, CSF | 26598-3 |
| 2011984 | Tryptophan, CSF | 26602-3 |
| 2011985 | Alpha-amino butyric acid, CSF | 26586-8 |
| 2011986 | Allo-isoleucine, CSF | 22658-9 |
| 2011987 | Alpha-aminoadipic acid, CSF | 26587-6 |
| 2011988 | Anserine, CSF | 26588-4 |
| 2011989 | Argininosuccinic Acid, CSF | 40838-5 |
| 2011990 | Beta-alanine, CSF | 26589-2 |
| 2011991 | Beta-amino isobutyric acid, CSF | 26590-0 |
| 2011992 | Cystathionine, CSF | 26592-6 |
| 2011993 | Ethanolamine, CSF | 26593-4 |
| 2011994 | Gamma-amino butyric acid, CSF | 26594-2 |
Aliases
- CSF amino acids
- quantitative analysis of amino acids
